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Sigma
Diethylstilbestrol
D4628 -
≥99% (HPLC)
DOWNLOAD MSDS (PDF)Synonym: (E)
CAS Number: 56-53-1
Empirical Formula (Hill Notation): C18H20O2
Molecular Weight: 268.35
Beilstein Registry Number: 2056095
EC Number: 200-278-5
MDL number: MFCD00002373
PubChem Substance ID: 24893887
Properties
| Related Categories | Androgen Modulators, Bioactive Small Molecules, Cancer Research, Carcinogens, Cell Biology, |
| assay | ≥99% (HPLC) |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... ESR1(2099), ESR2(2100), ESRRG(2104) mouse ... Esr1(13982) rat ... Ar(24208), Esr1(24890) |
Description
Biochem/physiol Actions
Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.
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Documents
Certificate of Analysis
Certificate of Origin
| Gene Information |
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Safety Information
| Symbol |    GHS07, GHS08, GHS09 |
| Signal word | Danger |
| Hazard statements | H315-H319-H335-H350-H360-H410 |
| Precautionary statements | P201-P261-P273-P305 + P351 + P338-P308 + P313-P501 |
| Personal Protective Equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T,N |
| Risk Statements | 45-61-36/37/38-51/53 |
| Safety Statements | 53-36/37/39-45-60-61 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | WJ5600000 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
Articles
Carcinogenesis and Epigenetics
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Transcription, transformation
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